منابع مشابه
Types of glioma brain tumors and genetic alterations in signaling pathways in them
Types of glioma brain tumors and genetic alterations in signaling pathways in them Background & Objective: Glioma is a common type of primary brain tumor originating in the glial cells that surrounds and supports neurons in the brain. These tumors arise from three different types of cells that are normally found in the brain: astrocytes, oligodendrocytes, and ependymal cells, accordingly types ...
متن کاملGermline Variation Controls the Architecture of Somatic Alterations in Tumors
Studies have suggested that somatic events in tumors can depend on an individual's constitutional genotype. We used squamous cell carcinomas (SCC) of the skin, which arise in high multiplicity in organ transplant recipients, as a model to compare the pattern of somatic alterations within and across individuals. Specifically, we performed array comparative genomic hybridization on 104 tumors fro...
متن کاملTherapy-Induced Morphological Alterations in Brain Tumors
Routine therapeutic options for tumors of the brain or spinal cord comprise surgery, radiation and/or chemotherapy, all of which are associated with several possible complications. The most important consequences of brain tumor therapy are hemorrhage, acute brain swelling with external herniation of parts of the brain, CSF leaks, and coagulopathies. The anatomical location of surgical manipulat...
متن کاملGenetic alterations of IDH1 and Vegf in brain tumors
BACKGROUND This study evaluates the presence of R132H mutation in isocitrate dehydrogenase (IDH1) gene and the vascular endothelial growth factor (VEGF) +936 C/T polymorphism in brain tumors. The impact of these genetic alterations on overall survival (OS) and progression free survival (PFS) was evaluated. METHODS A cohort of 80 patients surgically treated at Hospital Clínico San Carlos, Madr...
متن کاملHeavy Metals and Epigenetic Alterations in Brain Tumors
Heavy metals and their derivatives can cause various diseases. Numerous studies have evaluated the possible link between exposure to heavy metals and various cancers. Recent data show a correlation between heavy metals and aberration of genetic and epigenetic patterns. From a literature search we noticed few experimental and epidemiological studies that evaluate a possible correlation between h...
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ژورنال
عنوان ژورنال: Oncology Reports
سال: 2008
ISSN: 1021-335X,1791-2431
DOI: 10.3892/or.20.1.203